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Azoxystrobin
25%SC  50%WG
INTRODUCTION
 
Azoxystrobin is a broad spectrum fungicide with activity against several diseases on many edible crops and ornamental plants. Some diseases controlled or prevented are rice blast, rusts, downy mildew, powdery mildew, late blight, apple scab, and Septoria. For cereals, rice, grapes, potatoes, vegetables, fruit trees and other crops, the safety of these crops.
 
TOXICOLOGICAL EFFECTS
 
ACUTE TOXICITY
 
The acute rat oral LD50 was >5,000 mg/kg. The acute rat dermal LD50 was >2,000 mg/kg. The acute inhalation LC50 in rats was 962 mg/l for males and 698 mg/l for females. Azoxystrobin was not a skin sensitizer in guinea pigs. The active ingredient was found to be a slight irritant in rabbits for both eyes and skin.
 
There were no corneal effects. Based on these results, Azoxystrobin was classified as Toxicity Category IV for acute oral toxicity and skin irritation, and Category III for acute dermal, inhalation and eye irritation.
 
CHRONIC TOXICITY
 
Azoxystrobin is non-oncogenic in the rat. Based on a study which administered Azoxystrobin in the diets of rats the following values were recorded: male rat 3.6 mg/kg/day, female rat 3.6 mg/kg/day at 60 ppm diet; male rat 18.2 mg/kg/day, female rat 22.3 mg/kg/day at 300 ppm diet; male rat 82.4 mg/kg/day, female rat 117.6 mg/kg/day at 1500/750 ppm diet, respectively.
 
The No Observed Effect Level (NOEL/NOAEL) for Azoxystrobin in the rat is 18 mg/kg bwt/day. The Reference Dose (RfD) for Azoxystrobin should be based upon the NOAEL of 18 mg/kg bwt/day with an uncertainty factor of 100, RfD = 0.18 mg/kg bwt/day.
 
A dietary inclusion level of 1,500 ppm was established as a Maximum Tolerated Dose (MTD) in female rats, where decrements in body weight gain relative to control of approximately 19 percent at week 53 and 11 percent at week 105 were observed. The maximum reduction relative to control was seen at week 73 (approximately 20 percent). In male rats, this dose level was in excess of an MTD (biliary toxicity), resulting in a reduction in the top dose level from 1,500 ppm to 750 ppm for the second year of the study. Reductions in male body weight gain relative to control animals were seen throughout the duration of the study with a maximum reduction of approximately 11 percent in the first year (at week 45), continuing into the second year (maximum reduction of approximately 13 percent at week 99).
 
In the rat, there was no statistical increase in the number of tumor- bearing animals, animals with malignant tumors, benign tumors, multiple tumors, single tumors or metastic tumors in animals treated with Azoxystrobin at dose levels of up to 1,500 ppm (up to 117.1 mg Azoxystrobin/kg bwt/day) for 2 years.
 
Azoxystrobin is of low subchronic toxicity in 21-day dermal testing.
 
PHYSICAL PROPERTIES AND GUIDELINES
 
Technical Azoxystrobin is a white crystalline solid.


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