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Amitraz
12.5%  20%EC
INTRODUCTION
 
Amitraz is a triazapentadiene compound, a member of the amidine chemical family . It is an insecticide and acaricide used to control red spider mites, leaf miners, scale insects, and aphids. On cotton it is used to control bollworms, white fly, and leaf worms. On animals it is used to control ticks, mites, lice and other animal pests .The EPA classifies Amitraz as Class III - slightly toxic. However, products containing it bear the SIGNAL WORD: CAUTION .
 
TOXICOLOGICAL
 
ACUTE TOXICITY
 
Amitraz is slightly toxic to mammals if ingested orally. The dose of Amitraz that is lethal to half of the test animals that ingest it is called the median lethal dose, or the LD50. The oral LD50 is 523- 800 mg/kg for Amitraz in rats (1, 3, 4, 9). The oral LD50 is greater than 1,600 mg/kg for mice. Dermal exposure results in an LD50 of greater than 1,600 mg/kg for rats and greater than 200 mg/kg for rabbits.
 
The Lethal Concentration 50 or LC50 is the concentration of the chemical in air or water that kills half of the experimental animals exposed to it. The inhalation LC50 (6 hours) of Amitraz for rats is 65 mg/l of air. Amitraz is not a skin irritant and does not sensitize skin.
 
Signs of acute Amitraz poisoning in male and female rats treated with 440 mg/kg and 365 mg/kg respectively, include coolness to touch, reduced spontaneous activity, episodes of increased induced activity such as aggression in response to handling, and signs of general debilitation. Amitraz also may produce a slowly reversible emaciation in survivors.
 
CHRONIC TOXICITY
 
In two-year feeding trials, rats who received 50 mg/kg/day in their diet and dogs who received 0.25 mg/kg/day of Amitraz did not show any ill-effects.
Formulation and specification:

 
12.5% EC
20% EC
Amitraz content ,%(m/m)
12.5 min
20.0 min
Moisture ,%(m/m)
0.5 max
0.5 max
Acidity(as H2SO4), %(m/m)
0.5 max
0.5 max
Emulsion stability
Qualified
Qualified



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